Prolyl 3-hydroxylase OGFOD1

BE0002210ProteinHumansOGFOD1

Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. It is acted on by 1 drug in DrugBank.

Gene name
OGFOD1
UniProtKB entry
Q8N543Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
542 residues · 63,246 Da
Also known as
1.14.11.- · 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 · KIAA1612 · Termination and polyadenylation 1 homolog · TPA1

Resolves to

Protein
UniProtQ8N543UniProt nameOGFD1_HUMAN
Gene
HGNCHGNC:25585NCBI Gene55239GenBank21410525GeneCardsOGFOD1
Pharmacology
KEGGhsa:55239
Structure
PDB4NHXPDB4NHY
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolyl 3-hydroxylase OGFOD1, how selective are they, and which programs against it are still in active trials?

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