Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

BE0002213ProteinHumansALKBH3

Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A) (PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). It is acted on by 1 drug in DrugBank.

Gene name
ALKBH3
UniProtKB entry
Q96Q83Swiss-Prot
Cellular location
Nucleus
Residues / weight
286 residues · 33,374 Da
Also known as
1.14.11.33 · 1.14.11.54 · ABH3 · Alkylated DNA repair protein alkB homolog 3 · DEPC-1

Resolves to

Protein
UniProtQ96Q83UniProt nameALKB3_HUMAN
Gene
HGNCHGNC:30141NCBI Gene221120GenBank16326129GeneCardsALKBH3
Pharmacology
KEGGhsa:221120
Structure
PDB2IUWPDB8JNKPDB8JNR
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3, how selective are they, and which programs against it are still in active trials?

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