Lysine-specific demethylase 5D

BE0002215ProteinHumansKDM5D

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. It is acted on by 1 drug in DrugBank.

Gene name
KDM5D
UniProtKB entry
Q9BY66Swiss-Prot
Cellular location
Nucleus
Residues / weight
1,539 residues · 174,071 Da
Also known as
[histone H3]-trimethyl-L-lysine(4) demethylase 5D · 1.14.11.67 · H-Y · Histocompatibility Y antigen · Histone demethylase JARID1D

Resolves to

Protein
UniProtQ9BY66UniProt nameKDM5D_HUMAN
Gene
HGNCHGNC:11115NCBI Gene8284GenBank1661016GeneCardsKDM5D
Pharmacology
KEGGhsa:8284
Structure
PDB2E6RPDB2YQE
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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7Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Lysine-specific demethylase 5D, how selective are they, and which programs against it are still in active trials?

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