Trimethyllysine dioxygenase, mitochondrial

BE0002221ProteinHumansTMLHE

Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) in the carnitine biosynthesis pathway. It is acted on by 1 drug in DrugBank.

Gene name
TMLHE
UniProtKB entry
Q9NVH6Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
421 residues · 49,517 Da
Also known as
1.14.11.8 · Epsilon-trimethyllysine 2-oxoglutarate dioxygenase · Epsilon-trimethyllysine hydroxylase · TML dioxygenase · TML hydroxylase

Resolves to

Protein
UniProtQ9NVH6UniProt nameTMLH_HUMAN
Gene
HGNCHGNC:18308NCBI Gene55217GenBank15553435GeneCardsTMLHE
Pharmacology
KEGGhsa:55217
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Trimethyllysine dioxygenase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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