Transmembrane prolyl 4-hydroxylase

BE0002223ProteinHumansP4HTM

Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. It is acted on by 1 drug in DrugBank.

Gene name
P4HTM
UniProtKB entry
Q9NXG6Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
502 residues · 56,661 Da
Also known as
1.14.11.29 · HIF-PH4 · HIF-prolyl hydroxylase 4 · HPH-4 · Hypoxia-inducible factor prolyl hydroxylase 4

Resolves to

Protein
UniProtQ9NXG6UniProt nameP4HTM_HUMAN
Gene
HGNCHGNC:28858NCBI Gene54681GenBank28566186GeneCardsP4HTM
Pharmacology
KEGGhsa:54681
Structure
PDB6TP5
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Transmembrane prolyl 4-hydroxylase, how selective are they, and which programs against it are still in active trials?

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