Cyclin-dependent kinase 8

BE0002224ProteinHumansCDK8

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It is acted on by 3 drugs in DrugBank.

Gene name
CDK8
UniProtKB entry
P49336Swiss-Prot
Cellular location
Nucleus
Residues / weight
464 residues · 53,283 Da
Also known as
2.7.11.22 · 2.7.11.23 · Cell division protein kinase 8 · Mediator complex subunit CDK8 · Mediator of RNA polymerase II transcription subunit CDK8

Resolves to

Protein
UniProtP49336UniProt nameCDK8_HUMAN
Gene
HGNCHGNC:1779NCBI Gene1024GenBank1000491GeneCardsCDK8
Pharmacology
IUPHAR/GtoPdb1980KEGGhsa:1024
Structure
PDB3RGFPDB4CRLPDB4F6S
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Cyclin-dependent kinase 8, and which indications are they being tested in?

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