Alvocidib

DB03496InvestigationalSmall molecule

Alvocidib is a synthetic flavonoid based on an extract from an Indian plant for the potential treatment of cancer. It works by inhibiting cyclin-dependent kinases, arresting cell division and causing...

Chemical structure of Alvocidib
Mechanism
Curator reviewed
Primary indication
Investigated for use/treatment in esophageal cancer, leukemia (lymphoid), lung cancer, liver cancer, and lymphoma (unspecified).Curator reviewed
Formula / weight
C21H20ClNO5 · 401.84 g/mol (avg)
Also known as
Alvocidib freebase · Flavopiridol
Code names
L86-8275

Resolves to

Compound
UNII45AD6X575GCAS146426-40-6ChEMBLCHEMBL428690ChEBI47344PubChem5287969
Clinical / RWD
PharmGKBPA452627
Structure
InChIKeyBIIVYFLTOXDAOV-YVEFUNNKSA-NSMILESCN1CC[C@@H]([C@H](O)C1)C1=C(O)C=C(O)C2=C1OC(=CC2=O)C1=CC=CC=C1Cl
Targets
P11217PYGMP50750CDK9P50613CDK7P06493CDK1Q00534CDK6P11802CDK4P24941CDK2P11216PYGB+4 more
Transporters
Q9UNQ0ABCG2

What you can answer from here — as of September 23, 2026

12Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
1TransporterSubstrate / inhibitor direction, not just membership
Listed above
200Drug interactionsStructured to mechanism, not free text
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51Clinical trialsPhase, status and sponsor resolved per trial
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37+ReferencesStructured and connected to the statements they support
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