Isoaspartyl peptidase/L-asparaginase

BE0002230ProteinHumansASRGL1

Has both L-asparaginase and beta-aspartyl peptidase activity. It is acted on by 3 drugs in DrugBank.

Gene name
ASRGL1
UniProtKB entry
Q7L266Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
308 residues · 32,054 Da
Also known as
3.4.19.5 · 3.5.1.1 · ALP · Asparaginase-like protein 1 · Beta-aspartyl-peptidase

Resolves to

Protein
UniProtQ7L266UniProt nameASGL1_HUMAN
Gene
HGNCHGNC:16448NCBI Gene80150GenBank127798426GeneCardsASRGL1
Pharmacology
KEGGhsa:80150
Structure
PDB3TKJPDB4ET0PDB4O0C
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isoaspartyl peptidase/L-asparaginase, how selective are they, and which programs against it are still in active trials?

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