Adenylosuccinate synthetase isozyme 1

BE0002231ProteinHumansADSS1

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. It is acted on by 7 drugs in DrugBank.

Gene name
ADSS1
UniProtKB entry
Q8N142Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
457 residues · 50,208 Da
Also known as
6.3.4.4 · Adenylosuccinate synthetase-like 1 · Adenylosuccinate synthetase, basic isozyme · Adenylosuccinate synthetase, muscle isozyme · AdSS 1

Resolves to

Protein
UniProtQ8N142UniProt namePURA1_HUMAN
Gene
HGNCHGNC:20093NCBI Gene122622GenBank21303413GeneCardsADSS1
Pharmacology
KEGGhsa:122622
Drugs

What you can answer from here — as of September 07, 2019

7DrugsApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Adenylosuccinate synthetase isozyme 1, and which indications are they being tested in?

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