Phosphoribosylformylglycinamidine synthase

BE0002235ProteinHumansPFAS

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. It is acted on by 2 drugs in DrugBank.

Gene name
PFAS
UniProtKB entry
O15067Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
1,338 residues · 144,733 Da
Also known as
6.3.5.3 · FGAM synthase · FGAMS · FGAR amidotransferase · FGAR-AT

Resolves to

Protein
UniProtO15067UniProt namePUR4_HUMAN
Gene
HGNCHGNC:8863NCBI Gene5198GenBank2224663GeneCardsPFAS
Pharmacology
KEGGhsa:5198
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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5GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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14+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Phosphoribosylformylglycinamidine synthase, how selective are they, and which programs against it are still in active trials?

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