Glutamine-dependent NAD(+) synthetase

BE0002244ProteinHumansNADSYN1

Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source. It is acted on by 2 drugs in DrugBank.

Gene name
NADSYN1
UniProtKB entry
Q6IA69Swiss-Prot
Residues / weight
706 residues · 79,284 Da
Also known as
6.3.5.1 · NAD(+) synthase [glutamine-hydrolyzing] · NAD(+) synthetase

Resolves to

Protein
UniProtQ6IA69UniProt nameNADE_HUMAN
Gene
HGNCHGNC:29832NCBI Gene55191GenBank28849201GeneCardsNADSYN1
Pharmacology
KEGGhsa:55191
Structure
PDB6OFB
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamine-dependent NAD(+) synthetase, how selective are they, and which programs against it are still in active trials?

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