b(0,+)-type amino acid transporter 1

BE0002251ProteinHumansSLC7A9

Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (PubMed:16825196, PubMed:32494597, PubMed:32817565, PubMed:8663357). It is acted on by 2 drugs in DrugBank.

Gene name
SLC7A9
UniProtKB entry
P82251Swiss-Prot
Cellular location
Apical cell membrane
Residues / weight
487 residues · 53,481 Da
Also known as
b(0,+)AT1 · BAT1 · Glycoprotein-associated amino acid transporter b0,+AT1 · Solute carrier family 7 member 9

Resolves to

Protein
UniProtP82251UniProt nameBAT1_HUMAN
Gene
HGNCHGNC:11067NCBI Gene11136GenBank5916108GeneCardsSLC7A9
Pharmacology
KEGGhsa:11136
Structure
PDB6LI9PDB6LIDPDB6YUP
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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19+ReferencesStructured and connected to the statements they support
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Which approved drugs act on b(0,+)-type amino acid transporter 1, how selective are they, and which programs against it are still in active trials?

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