Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

BE0002252ProteinHumansSDHD

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:10482792, PubMed:9533030). It is acted on by 3 drugs in DrugBank.

Gene name
SDHD
UniProtKB entry
O14521Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
159 residues · 17,043 Da
Also known as
CII-4 · CybS · Malate dehydrogenase [quinone] cytochrome b small subunit · QPs3 · SDH4

Resolves to

Protein
UniProtO14521UniProt nameDHSD_HUMAN
Gene
HGNCHGNC:10683NCBI Gene6392GenBank2351037GeneCardsSDHD
Pharmacology
KEGGhsa:6392
Structure
PDB8GS8PDB9KC4
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
3Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
6GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
28+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In