Hexachlorophene

DB00756ApprovedWithdrawnSmall moleculeAnti-Infective Agents, Local

Hexachlorophene is a chlorinated bisphenol antiseptic used as a surgical scrub and skin cleanser. A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms.

Mechanism: The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Curator reviewed
Primary indication: For use as a surgical scrub and a bacteriostatic skin cleanser.Curator reviewed · 3 structured indications
Formula / weight: C₁₃H₆Cl₆O₂ · 406.904 g/mol (avg)
First approval: Canada, 2006 · United States, 1976
Code names: NSC-49115 · RCRA Waste Number U132

Resolves to

Compound

UNIIIWW5FV6NK2CAS70-30-4ChEMBLCHEMBL496ChEBI5693PubChem3598KEGGD00859

Clinical / RWD

RxNorm5293ATCD08AE01PharmGKBPA449871

Structure

InChIKeyACGUYXCXAPNIKK-UHFFFAOYSA-NSMILESOC1=C(CC2=C(O)C(Cl)=CC(Cl)=C2Cl)C(Cl)=C(Cl)C=C1Cl

Targets

P06149dldP0AEK4fabIO14521SDHDP00367GLUD1P03372ESR1

What you can answer from here — as of September 23, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

8Clinical trialsPhase, status and sponsor resolved per trial

3Structured indicationsCondition, population, route and combination as fields, not prose

10ContraindicationsEach with its own population and attribute set

7Marketed productsAcross 4 countries and 6 labellers

1ATC codeIncluding every combination product, plus 11 drug categories

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Hexachlorophene, and which of those have an active Phase 3 trial?

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