Prolyl 4-hydroxylase subunit alpha-2

BE0002253ProteinHumansP4HA2

Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. It is acted on by 1 drug in DrugBank.

Gene name
P4HA2
UniProtKB entry
O15460Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
535 residues · 60,901 Da
Also known as
1.14.11.2 · 4-PH alpha-2 · Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2

Resolves to

Protein
UniProtO15460UniProt nameP4HA2_HUMAN
Gene
HGNCHGNC:8547NCBI Gene8974GenBank2439985GeneCardsP4HA2
Pharmacology
KEGGhsa:8974
Structure
PDB6EVLPDB6EVMPDB6EVN
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Prolyl 4-hydroxylase subunit alpha-2, how selective are they, and which programs against it are still in active trials?

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