DB00172ApprovedInvestigationalNutraceuticalSmall molecule
Proline is an amino acid commonly found as a component of total parenteral nutrition. Proline is one of the twenty amino acids used in living organisms as the building blocks of proteins.
- Mechanism
- Curator reviewed
Glycogenic, by L-Proline oxidase in the kidney, it is ring-opened and is oxidized to form L-Glutamic acid. L-Ornithine and L-Glutamic acid are converted to L-Proline via L-Glutamic acid-gamma-semialdehyde. It is contained abundantly in collagen, and is intimately involved in the function of arthrosis and chordae.
- Primary indication
- L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.Curator reviewed · 1 structured indication
- Formula / weight
- C5H9NO2 · 115.1305 g/mol (avg)
- First approval
- Canada, 1997 · United States, 1971
- Also known as
- L-Prolin · L-Proline
- Code names
- FEMA NO. 3319 · NSC-46703
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
ONIBWKKTOPOVIA-BYPYZUCNSA-NSMILESOC(=O)[C@@H]1CCCN1Targets
Transporters
What you can answer from here — as of September 23, 2026
22Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
1TransporterSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Proline, and which of those have an active Phase 3 trial?
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