Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

BE0002256ProteinHumansOXCT1

Key enzyme for ketone body catabolism. It is acted on by 2 drugs in DrugBank.

Gene name
OXCT1
UniProtKB entry
P55809Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
520 residues · 56,157 Da
Also known as
2.8.3.5 · 3-oxoacid CoA-transferase 1 · OXCT · SCOT · SCOT-s

Resolves to

Protein
UniProtP55809UniProt nameSCOT1_HUMAN
Gene
HGNCHGNC:8527NCBI Gene5019GenBank1519052GeneCardsOXCT1
Pharmacology
KEGGhsa:5019
Structure
PDB3DLX
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial, how selective are they, and which programs against it are still in active trials?

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