Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

BE0002257ProteinHumansSDHC

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:9533030). It is acted on by 3 drugs in DrugBank.

Gene name
SDHC
UniProtKB entry
Q99643Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
169 residues · 18,610 Da
Also known as
CYB560 · CYBL · Integral membrane protein CII-3 · Malate dehydrogenase [quinone] cytochrome b560 subunit · QPs-1

Resolves to

Protein
UniProtQ99643UniProt nameC560_HUMAN
Gene
HGNCHGNC:10682NCBI Gene6391GenBank1814226GeneCardsSDHC
Pharmacology
KEGGhsa:6391
Structure
PDB8GS8PDB9KC4
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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3Clinical trialsTrials of drugs acting on it, by phase and status
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6GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Succinate dehydrogenase cytochrome b560 subunit, mitochondrial, how selective are they, and which programs against it are still in active trials?

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