Succinate receptor 1

BE0002258ProteinHumansSUCNR1

G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (By similarity) (PubMed:15141213, PubMed:23770096, PubMed:34133934). It is acted on by 1 drug in DrugBank.

Gene name
SUCNR1
UniProtKB entry
Q9BXA5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
334 residues · 38,697 Da
Also known as
G protein-coupled receptor 91 · GPR91 · P2Y purinoceptor 1-like

Resolves to

Protein
UniProtQ9BXA5UniProt nameSUCR1_HUMAN
Gene
HGNCHGNC:4542NCBI Gene56670GenBank13517983GeneCardsSUCNR1
Pharmacology
IUPHAR/GtoPdb166KEGGhsa:56670
Structure
PDB8JPNPDB8JPPPDB8WOG
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Succinate receptor 1, how selective are they, and which programs against it are still in active trials?

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