Mitochondrial dicarboxylate carrier

BE0002261ProteinHumansSLC25A10

Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:29211846, PubMed:38780415, PubMed:38937634). It is acted on by 1 drug in DrugBank.

Gene name
SLC25A10
UniProtKB entry
Q9UBX3Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
287 residues · 31,282 Da
Also known as
DIC · Solute carrier family 25 member 10

Resolves to

Protein
UniProtQ9UBX3UniProt nameDIC_HUMAN
Gene
HGNCHGNC:10980NCBI Gene1468GenBank6224534GeneCardsSLC25A10
Pharmacology
KEGGhsa:1468
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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14GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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6+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitochondrial dicarboxylate carrier, how selective are they, and which programs against it are still in active trials?

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