Beta-1,4-galactosyltransferase 4

BE0002263ProteinHumansB4GALT4

Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids (PubMed:12511560, PubMed:17690104, PubMed:32827291, PubMed:9792633). It is acted on by 1 drug in DrugBank.

Gene name
B4GALT4
UniProtKB entry
O60513Swiss-Prot
Cellular location
Golgi apparatus membrane
Residues / weight
344 residues · 40,041 Da
Also known as
2.4.1.- · b4Gal-T4 · Beta-1,4-GalTase 4 · Beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase · Beta4Gal-T4

Resolves to

Protein
UniProtO60513UniProt nameB4GT4_HUMAN
Gene
HGNCHGNC:927NCBI Gene8702GenBank3132900GeneCardsB4GALT4
Pharmacology
KEGGhsa:8702
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Beta-1,4-galactosyltransferase 4, how selective are they, and which programs against it are still in active trials?

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