N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

BE0002266ProteinHumansNAGPA

Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P-mannose moieties, which are formed in the first step. It is acted on by 1 drug in DrugBank.

Gene name
NAGPA
UniProtKB entry
Q9UK23Swiss-Prot
Cellular location
Golgi apparatus, Golgi stack membrane
Residues / weight
515 residues · 56,072 Da
Also known as
3.1.4.45 · Mannose 6-phosphate-uncovering enzyme · Phosphodiester alpha-GlcNAcase

Resolves to

Protein
UniProtQ9UK23UniProt nameNAGPA_HUMAN
Gene
HGNCHGNC:17378NCBI Gene51172GenBank6425040GeneCardsNAGPA
Pharmacology
KEGGhsa:51172
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, how selective are they, and which programs against it are still in active trials?

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