5-oxoprolinase

BE0002268ProteinHumansOPLAH

Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. It is acted on by 2 drugs in DrugBank.

Gene name
OPLAH
UniProtKB entry
O14841Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
1,288 residues · 137,456 Da
Also known as
3.5.2.9 · 5-OPase · 5-oxo-L-prolinase · Pyroglutamase

Resolves to

Protein
UniProtO14841UniProt nameOPLA_HUMAN
Gene
HGNCHGNC:8149NCBI Gene26873GenBank46020040GeneCardsOPLAH
Pharmacology
KEGGhsa:26873
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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2GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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11+ReferencesStructured and connected to the statements they support
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Which approved drugs act on 5-oxoprolinase, how selective are they, and which programs against it are still in active trials?

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