Glutamyl aminopeptidase

BE0002271ProteinHumansENPEP

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. It is acted on by 3 drugs in DrugBank.

Gene name
ENPEP
UniProtKB entry
Q07075Swiss-Prot
Cellular location
Cell membrane
Residues / weight
957 residues · 109,244 Da
Also known as
3.4.11.7 · Aminopeptidase A · AP-A · Differentiation antigen gp160 · EAP

Resolves to

Protein
UniProtQ07075UniProt nameAMPE_HUMAN
Gene
HGNCHGNC:3355NCBI Gene2028GenBank291854GeneCardsENPEP
Pharmacology
KEGGhsa:2028
Structure
PDB4KX7PDB4KX8PDB4KX9
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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17+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutamyl aminopeptidase, how selective are they, and which programs against it are still in active trials?

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