Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

BE0002272ProteinHumansEARS2

Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation (PubMed:19805282). It is acted on by 1 drug in DrugBank.

Gene name
EARS2
UniProtKB entry
Q5JPH6Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
523 residues · 58,688 Da
Also known as
6.1.1.24 · GluRS · Glutamate--tRNA(Gln) ligase EARS2, mitochondrial · Glutamyl-tRNA synthetase · KIAA1970

Resolves to

Protein
UniProtQ5JPH6UniProt nameSYEM_HUMAN
Gene
HGNCHGNC:29419NCBI Gene124454GenBank57997136GeneCardsEARS2
Pharmacology
KEGGhsa:124454
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial, how selective are they, and which programs against it are still in active trials?

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