N-acetylglutamate synthase, mitochondrial

BE0002274ProteinHumansNAGS

Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. It is acted on by 3 drugs in DrugBank.

Gene name
NAGS
UniProtKB entry
Q8N159Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
534 residues · 58,156 Da
Also known as
2.3.1.1 · Amino-acid acetyltransferase

Resolves to

Protein
UniProtQ8N159UniProt nameNAGS_HUMAN
Gene
HGNCHGNC:17996NCBI Gene162417GenBank22651769GeneCardsNAGS
Pharmacology
KEGGhsa:162417
Structure
PDB4K30
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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5GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on N-acetylglutamate synthase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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