Mitochondrial glutamate carrier 2

BE0002275ProteinHumansSLC25A18

Responsible for the transport of glutamate from the cytosol into the mitochondrial matrix with the concomitant import of a proton (symport system). It is acted on by 1 drug in DrugBank.

Gene name
SLC25A18
UniProtKB entry
Q9H1K4Swiss-Prot
Cellular location
Mitochondrion inner membrane
Residues / weight
315 residues · 33,848 Da
Also known as
GC-2 · GC2 · Glutamate/H(+) symporter 2 · Solute carrier family 25 member 18

Resolves to

Protein
UniProtQ9H1K4UniProt nameGHC2_HUMAN
Gene
HGNCHGNC:10988NCBI Gene83733GenBank21322707GeneCardsSLC25A18
Pharmacology
KEGGhsa:83733
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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8GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Mitochondrial glutamate carrier 2, how selective are they, and which programs against it are still in active trials?

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