Aspartyl aminopeptidase

Details

Name
Aspartyl aminopeptidase
Kind
protein
Synonyms
  • 3.4.11.21
  • ASPEP
  • DAP
Gene Name
DNPEP
UniProtKB Entry
Q9ULA0Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0063980|Aspartyl aminopeptidase
MSGHSPTRGAMQVAMNGKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAGFSEL
KETEKWNIKPESKYFMTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRRSRRSQ
VGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVKCPTSGRLEQQLVHVERPILRIPHLAIH
LQRNINENFGPNTEMHLVPILATAIQEELEKGTPEPGPLNAVDERHHSVLMSLLCAHLGL
SPKDIVEMELCLADTQPAVLGGAYDEFIFAPRLDNLHSCFCALQALIDSCAGPGSLATEP
HVRMVTLYDNEEVGSESAQGAQSLLTELVLRRISASCQHPTAFEEAIPKSFMISADMAHA
VHPNYLDKHEENHRPLFHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPLQDLMVRND
TPCGTTIGPILASRLGLRVLDLGSPQLAMHSIREMACTTGVLQTLTLFKGFFELFPSLSH
NLLVD
Number of residues
485
Molecular Weight
53409.95
Theoretical pI
7.44
GO Classification
Functions
aminopeptidase activity / metallopeptidase activity / zinc ion binding
Processes
peptide metabolic process
Components
blood microparticle / cytoplasm / nucleus
General Function
Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism
Specific Function
aminopeptidase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019259|Aspartyl aminopeptidase (DNPEP)
ATGAGCGGACACAGCCCCACGCGCGGGGCCATGCAGGTGGCCATGAACGGTAAGGCCCGC
AAAGAGGCGGTGCAGACTGCGGCTAAGGAACTCCTCAAGTTCGTGAACCGGAGTCCCTCT
CCTTTCCATGCTGTGGCTGAATGCCGCAACCGCCTTCTCCAGGCTGGCTTCAGTGAACTC
AAGGAGACTGAGAAATGGAATATTAAGCCCGAGAGCAAGTACTTCATGACCAGGAACTCC
TCCACCATCATAGCTTTTGCTGTAGGGGGCCAGTACGTTCCTGGCAATGGCTTCAGCCTC
ATCGGGGCCCACACGGACAGCCCCTGCCTCCGGGTGAAACGTCGGTCTCGCCGCAGCCAG
GTGGGCTTCCAGCAAGTCGGTGTGGAGACCTATGGTGGTGGGATCTGGAGCACCTGGTTT
GACCGTGACCTGACTCTGGCTGGACGCGTCATTGTCAAGTGCCCTACCTCAGGTCGGCTG
GAGCAGCAGCTGGTGCACGTGGAGCGGCCCATTCTTCGCATCCCACACCTGGCCATCCAT
CTGCAGCGAAATATCAACGAGAACTTTGGGCCCAACACAGAGATGCATCTAGTCCCCATT
CTTGCCACAGCCATCCAGGAGGAGCTGGAGAAGGGGACTCCTGAGCCAGGGCCTCTCAAT
GCTGTGGATGAGCGGCACCATTCGGTCCTCATGTCCCTGCTCTGTGCCCATCTGGGGCTG
AGCCCCAAGGACATAGTGGAGATGGAGCTCTGCCTTGCAGACACCCAGCCTGCGGTCTTG
GGTGGTGCCTATGATGAGTTCATCTTTGCTCCTCGGCTGGACAATCTGCACAGCTGCTTC
TGTGCCCTGCAGGCCTTGATAGATTCCTGTGCAGGCCCTGGCTCCCTGGCCACAGAGCCT
CACGTGCGCATGGTCACACTCTATGACAACGAAGAGGTGGGGTCTGAGAGTGCACAGGGA
GCACAGTCACTGCTGACAGAGCTGGTGCTGCGGCGGATCTCAGCCTCGTGCCAGCACCCG
ACAGCCTTCGAGGAAGCCATACCCAAGTCCTTCATGATCAGCGCAGACATGGCCCATGCT
GTGCATCCCAACTACCTGGACAAGCATGAGGAGAACCACCGGCCTTTATTCCACAAGGGC
CCCGTGATCAAGGTGAACAGCAAGCAACGCTATGCTTCAAACGCGGTGTCAGAGGCCCTG
ATCCGAGAGGTGGCCAACAAAGTCAAGGTCCCCCTGCAGGATCTCATGGTCCGGAATGAC
ACCCCCTGTGGAACCACCATTGGACCTATCTTGGCTTCTCGGCTGGGGCTGCGGGTGCTG
GATTTAGGCAGCCCCCAACTGGCCATGCACTCTATCCGGGAGATGGCCTGCACCACAGGA
GTCCTCCAGACCCTCACCCTCTTCAAGGGCTTCTTTGAGCTGTTCCCTTCTCTAAGCCAT
AATCTCTTAGTGGATTGA
Chromosome Location
2
Locus
2q35
External Identifiers
ResourceLink
UniProtKB IDQ9ULA0
UniProtKB Entry NameDNPEP_HUMAN
GenBank Protein ID5902181
GenBank Gene IDAF005050
GeneCard IDDNPEP
GenAtlas IDDNPEP
HGNC IDHGNC:2981
PDB ID(s)4DYO
KEGG IDhsa:23549
IUPHAR/Guide To Pharmacology ID1559
NCBI Gene ID23549
General References
  1. Wilk S, Wilk E, Magnusson RP: Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. J Biol Chem. 1998 Jun 26;273(26):15961-70. [Article]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
  6. Van Damme P, Lasa M, Polevoda B, Gazquez C, Elosegui-Artola A, Kim DS, De Juan-Pardo E, Demeyer K, Hole K, Larrea E, Timmerman E, Prieto J, Arnesen T, Sherman F, Gevaert K, Aldabe R: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12449-54. doi: 10.1073/pnas.1210303109. Epub 2012 Jul 18. [Article]
  7. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  8. Chaikuad A, Pilka ES, De Riso A, von Delft F, Kavanagh KL, Venien-Bryan C, Oppermann U, Yue WW: Structure of human aspartyl aminopeptidase complexed with substrate analogue: insight into catalytic mechanism, substrate specificity and M18 peptidase family. BMC Struct Biol. 2012 Jun 21;12:14. doi: 10.1186/1472-6807-12-14. [Article]

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Glutamic acidapproved, nutraceuticalunknowntargetDetails
QGC-001investigationalyestargetinhibitorDetails