Glutathione S-transferase 3, mitochondrial

BE0002279ProteinHumansMGST3

Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:36370807, PubMed:9278457). It is acted on by 2 drugs in DrugBank.

Gene name
MGST3
UniProtKB entry
O14880Swiss-Prot
Cellular location
Mitochondrion outer membrane
Residues / weight
152 residues · 16,516 Da
Also known as
2.5.1.- · Glutathione peroxidase MGST3 · GST-3 · LTC4 synthase MGST3

Resolves to

Protein
UniProtO14880UniProt nameMGST3_HUMAN
Gene
HGNCHGNC:7064NCBI Gene4259GenBank2583081GeneCardsMGST3
Pharmacology
KEGGhsa:4259
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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10+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Glutathione S-transferase 3, mitochondrial, how selective are they, and which programs against it are still in active trials?

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