This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Generic Name
PF-06651600
DrugBank Accession Number
DB14924
Background

PF-06651600 is under investigation in clinical trial NCT02974868 (Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Subjects With Alopecia Areata).

Type
Small Molecule
Groups
Investigational
Structure
Weight
Average: 285.351
Monoisotopic: 285.158960252
Chemical Formula
C15H19N5O
Synonyms
Not Available

Pharmacology

Indication

Not Available

Reduce drug development failure rates
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Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
2OYE00PC25
CAS number
1792180-81-4
InChI Key
CBRJPFGIXUFMTM-WDEREUQCSA-N
InChI
InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
IUPAC Name
1-[(2S,5R)-2-methyl-5-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)piperidin-1-yl]prop-2-en-1-one
SMILES
C[C@H]1CC[C@H](CN1C(=O)C=C)NC1=NC=NC2=C1C=CN2

References

General References
Not Available
ChemSpider
59718512
BindingDB
209866
ChEMBL
CHEMBL4085457
ZINC
ZINC000526061581

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3Active Not RecruitingTreatmentAlopecia Areata (AA)1
2Active Not RecruitingOtherAlopecia Areata (AA)1
2CompletedTreatmentActive Non-segmental Vitiligo1
2CompletedTreatmentAlopecia Areata (AA)1
2CompletedTreatmentRheumatoid Arthritis2
2CompletedTreatmentUlcerative Colitis1
2RecruitingTreatmentCrohn's Disease (CD)1
2, 3CompletedTreatmentAlopecia Areata (AA)1
1CompletedBasic ScienceHealthy Females1
1CompletedBasic ScienceHealthy Subjects (HS)14

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
Not Available
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.457 mg/mLALOGPS
logP1.8ALOGPS
logP1.47ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)13.59ChemAxon
pKa (Strongest Basic)6.6ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area73.91 Å2ChemAxon
Rotatable Bond Count3ChemAxon
Refractivity82.84 m3·mol-1ChemAxon
Polarizability29.95 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created at May 20, 2019 14:35 / Updated at June 12, 2020 16:53