This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.
Identification
- Generic Name
- PF-06651600
- DrugBank Accession Number
- DB14924
- Background
PF-06651600 is under investigation in clinical trial NCT02974868 (Study To Evaluate The Efficacy And Safety Profile Of PF-06651600 And PF-06700841 In Subjects With Alopecia Areata).
- Type
- Small Molecule
- Groups
- Investigational
- Structure
- Weight
- Average: 285.351
Monoisotopic: 285.158960252 - Chemical Formula
- C15H19N5O
- Synonyms
- Not Available
Pharmacology
- Indication
Not Available
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Contraindications & Blackbox Warnings
- Avoid life-threatening adverse drug eventsImprove clinical decision support with information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events & improve clinical decision support.
- Pharmacodynamics
Not Available
- Mechanism of action
- Not Available
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates.Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- 2OYE00PC25
- CAS number
- 1792180-81-4
- InChI Key
- CBRJPFGIXUFMTM-WDEREUQCSA-N
- InChI
- InChI=1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
- IUPAC Name
- 1-[(2S,5R)-2-methyl-5-({7H-pyrrolo[2,3-d]pyrimidin-4-yl}amino)piperidin-1-yl]prop-2-en-1-one
- SMILES
- C[C@H]1CC[C@H](CN1C(=O)C=C)NC1=NC=NC2=C1C=CN2
References
- General References
- Not Available
- External Links
- ChemSpider
- 59718512
- BindingDB
- 209866
- ChEMBL
- CHEMBL4085457
- ZINC
- ZINC000526061581
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 3 Active Not Recruiting Treatment Alopecia Areata (AA) 1 2 Active Not Recruiting Other Alopecia Areata (AA) 1 2 Completed Treatment Active Non-segmental Vitiligo 1 2 Completed Treatment Alopecia Areata (AA) 1 2 Completed Treatment Rheumatoid Arthritis 2 2 Completed Treatment Ulcerative Colitis 1 2 Recruiting Treatment Crohn's Disease (CD) 1 2, 3 Completed Treatment Alopecia Areata (AA) 1 1 Completed Basic Science Healthy Females 1 1 Completed Basic Science Healthy Subjects (HS) 14
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source Water Solubility 0.457 mg/mL ALOGPS logP 1.8 ALOGPS logP 1.47 ChemAxon logS -2.8 ALOGPS pKa (Strongest Acidic) 13.59 ChemAxon pKa (Strongest Basic) 6.6 ChemAxon Physiological Charge 1 ChemAxon Hydrogen Acceptor Count 4 ChemAxon Hydrogen Donor Count 2 ChemAxon Polar Surface Area 73.91 Å2 ChemAxon Rotatable Bond Count 3 ChemAxon Refractivity 82.84 m3·mol-1 ChemAxon Polarizability 29.95 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at May 20, 2019 14:35 / Updated at June 12, 2020 16:53