Microsomal glutathione S-transferase 2

BE0002290ProteinHumansMGST2

Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). It is acted on by 3 drugs in DrugBank.

Gene name
MGST2
UniProtKB entry
Q99735Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
147 residues · 16,620 Da
Also known as
2.5.1.18 · Glutathione peroxidase MGST2 · GST2 · Leukotriene C4 synthase MGST2 · Microsomal glutathione S-transferase II

Resolves to

Protein
UniProtQ99735UniProt nameMGST2_HUMAN
Gene
HGNCHGNC:7063NCBI Gene4258GenBank1747521GeneCardsMGST2
Pharmacology
KEGGhsa:4258
Structure
PDB6SSRPDB6SSSPDB6SSU
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Microsomal glutathione S-transferase 2, how selective are they, and which programs against it are still in active trials?

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