Sphingomyelin phosphodiesterase 4

BE0002300ProteinHumansSMPD4

Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:16517606, PubMed:25180167). It is acted on by 2 drugs in DrugBank.

Gene name
SMPD4
UniProtKB entry
Q9NXE4Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
866 residues · 97,809 Da
Also known as
3.1.4.12 · KIAA1418 · Neutral sphingomyelinase 3 · Neutral sphingomyelinase III · nSMase-3

Resolves to

Protein
UniProtQ9NXE4UniProt nameNSMA3_HUMAN
Gene
HGNCHGNC:32949NCBI Gene55627GenBank7243217GeneCardsSMPD4
Pharmacology
KEGGhsa:55627
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Sphingomyelin phosphodiesterase 4, how selective are they, and which programs against it are still in active trials?

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