ND1251 is an orally active phosphodiesterase-4 (PDE4) inhibitor, a mechanism clinically proven to play a role in alleviating symptoms of depression. ND1251 is a very potent compound with a large... ND1251 may also have applications in other disorders, such as Alzheimer's disease, mild cognitive impairment, multiple sclerosis and certain respiratory diseases.
- Mechanism
- Curator reviewed
ND1251 works by inhibiting the enzyme phophodiesterase. This increases the intracellular concentration of cAMP, a second messenger, which regulates enzymes involved in energy metabolism and cell division. This appears to play an important role in brain function.
- Primary indication
- Investigated for use/treatment in depression.Curator reviewed
- Code names
- ND1251
Resolves to
What you can answer from here — as of April 02, 2025
Which drugs share a target with ND1251, and which of those have an active Phase 3 trial?
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