Bile acid-CoA:amino acid N-acyltransferase

BE0002303ProteinHumansBAAT

Catalyzes the amidation of bile acids (BAs) with the amino acids taurine and glycine (PubMed:12239217, PubMed:12810727, PubMed:2037576, PubMed:8034703). It is acted on by 2 drugs in DrugBank.

Gene name
BAAT
UniProtKB entry
Q14032Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
418 residues · 46,299 Da
Also known as
2.3.1.65 · BACAT · BAT · Bile acid-CoA thioesterase · Choloyl-CoA hydrolase

Resolves to

Protein
UniProtQ14032UniProt nameBAAT_HUMAN
Gene
HGNCHGNC:932NCBI Gene570GenBank532505GeneCardsBAAT
Pharmacology
KEGGhsa:570
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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9GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Bile acid-CoA:amino acid N-acyltransferase, how selective are they, and which programs against it are still in active trials?

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