Threonine--tRNA ligase, mitochondrial

BE0002317ProteinHumansTARS2

Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). It is acted on by 1 drug in DrugBank.

Gene name
TARS2
UniProtKB entry
Q9BW92Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
718 residues · 81,035 Da
Also known as
6.1.1.3 · TARSL1 · Threonyl-tRNA synthetase · Threonyl-tRNA synthetase-like 1 · ThrRS

Resolves to

Protein
UniProtQ9BW92UniProt nameSYTM_HUMAN
Gene
HGNCHGNC:30740NCBI Gene80222GenBank62897187GeneCardsTARS2
Pharmacology
KEGGhsa:80222
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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3GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Threonine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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