Alanine--tRNA ligase, mitochondrial

BE0002318ProteinHumansAARS2

Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). It is acted on by 1 drug in DrugBank.

Gene name
AARS2
UniProtKB entry
Q5JTZ9Swiss-Prot
Cellular location
Mitochondrion
Residues / weight
985 residues · 107,339 Da
Also known as
6.1.1.7 · AARSL · Alanyl-tRNA synthetase · AlaRS · KIAA1270

Resolves to

Protein
UniProtQ5JTZ9UniProt nameSYAM_HUMAN
Gene
HGNCHGNC:21022NCBI Gene57505GenBank6331226GeneCardsAARS2
Pharmacology
KEGGhsa:57505
Structure
PDB6NLQPDB6NLYPDB6NOW
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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12+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Alanine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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