Diacylglycerol kinase alpha

BE0002324ProteinHumansDGKA

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15544348, PubMed:2175712). It is acted on by 1 drug in DrugBank.

Gene name
DGKA
UniProtKB entry
P23743Swiss-Prot
Cellular location
Cytoplasm, cytosol
Residues / weight
735 residues · 82,630 Da
Also known as
2.7.1.107 · 2.7.1.93 · 80 kDa diacylglycerol kinase · DAG kinase alpha · DAGK

Resolves to

Protein
UniProtP23743UniProt nameDGKA_HUMAN
Gene
HGNCHGNC:2849NCBI Gene1606GenBank30823GeneCardsDGKA
Pharmacology
IUPHAR/GtoPdb3256KEGGhsa:1606
Structure
PDB1TUZPDB6IIE
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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9GO termsFunction, process and component, as structured annotations
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4Pfam domainsDomain architecture mapped to Pfam families and clans
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9+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Diacylglycerol kinase alpha, how selective are they, and which programs against it are still in active trials?

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