Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

BE0002325ProteinHumansPPP2CB

Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events (Probable). It is acted on by 2 drugs in DrugBank.

Gene name
PPP2CB
UniProtKB entry
P62714Swiss-Prot
Cellular location
Cytoplasm
Residues / weight
309 residues · 35,575 Da
Also known as
3.1.3.16 · PP2A-beta

Resolves to

Protein
UniProtP62714UniProt namePP2AB_HUMAN
Gene
HGNCHGNC:9300NCBI Gene5516GenBank35581GeneCardsPPP2CB
Pharmacology
KEGGhsa:5516
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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18+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, how selective are they, and which programs against it are still in active trials?

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