Isoleucine--tRNA ligase, mitochondrial

BE0002328ProteinHumansIARS2

Aminoacyl-tRNA synthetase that catalyzes the specific attachment of isoleucine to its cognate tRNA (tRNA(Ile)). It is acted on by 1 drug in DrugBank.

Gene name
IARS2
UniProtKB entry
Q9NSE4Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
1,012 residues · 113,791 Da
Also known as
6.1.1.5 · IleRS · Isoleucyl-tRNA synthetase

Resolves to

Protein
UniProtQ9NSE4UniProt nameSYIM_HUMAN
Gene
HGNCHGNC:29685NCBI Gene55699GeneCardsIARS2
Pharmacology
KEGGhsa:55699
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Isoleucine--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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