Peptidyl-prolyl cis-trans isomerase H

BE0002331ProteinHumansPPIH

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). It is acted on by 1 drug in DrugBank.

Gene name
PPIH
UniProtKB entry
O43447Swiss-Prot
Cellular location
Nucleus speckle
Residues / weight
177 residues · 19,208 Da
Also known as
5.2.1.8 · CYP20 · CYPH · PPIase H · Rotamase H

Resolves to

Protein
UniProtO43447UniProt namePPIH_HUMAN
Gene
HGNCHGNC:14651NCBI Gene10465GenBank2708309GeneCardsPPIH
Pharmacology
KEGGhsa:10465
Structure
PDB1MZWPDB1QOIPDB5O9Z
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
Sign in
3GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
14+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Peptidyl-prolyl cis-trans isomerase H, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In