Peptidyl-prolyl cis-trans isomerase G

BE0002334ProteinHumansPPIG

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). It is acted on by 2 drugs in DrugBank.

Gene name
PPIG
UniProtKB entry
Q13427Swiss-Prot
Cellular location
Nucleus matrix
Residues / weight
754 residues · 88,617 Da
Also known as
5.2.1.8 · CARS-cyclophilin · CARS-Cyp · CASP10 · Clk-associating RS-cyclophilin

Resolves to

Protein
UniProtQ13427UniProt namePPIG_HUMAN
Gene
HGNCHGNC:14650NCBI Gene9360GenBank1117968GeneCardsPPIG
Pharmacology
KEGGhsa:9360
Structure
PDB2GW2PDB2WFIPDB2WFJ
Drugs

What you can answer from here — as of September 07, 2019

2DrugsApproved to experimental, with action, bond type and pharmacological action
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2GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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15+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Peptidyl-prolyl cis-trans isomerase G, how selective are they, and which programs against it are still in active trials?

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