Probable proline--tRNA ligase, mitochondrial

BE0002336ProteinHumansPARS2

Mitochondrial aminoacyl-tRNA synthetase that catalyzes the specific attachment of the proline amino acid (aa) to the homologous transfer RNA (tRNA), further participating in protein synthesis. It is acted on by 1 drug in DrugBank.

Gene name
PARS2
UniProtKB entry
Q7L3T8Swiss-Prot
Cellular location
Mitochondrion matrix
Residues / weight
475 residues · 53,262 Da
Also known as
6.1.1.15 · Prolyl-tRNA synthetase · Prolyl-tRNA synthetase 2, mitochondrial · ProRS

Resolves to

Protein
UniProtQ7L3T8UniProt nameSYPM_HUMAN
Gene
HGNCHGNC:30563NCBI Gene25973GenBank39644604GeneCardsPARS2
Pharmacology
KEGGhsa:25973
Drugs

What you can answer from here — as of September 07, 2019

1DrugApproved to experimental, with action, bond type and pharmacological action
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1GO termFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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7+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Probable proline--tRNA ligase, mitochondrial, how selective are they, and which programs against it are still in active trials?

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