Trans-3-hydroxy-L-proline dehydratase

BE0002337ProteinHumansL3HYPDH

Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). It is acted on by 1 drug in DrugBank.

Gene name
L3HYPDH
UniProtKB entry
Q96EM0Swiss-Prot
Residues / weight
354 residues · 38,137 Da
Also known as
4.2.1.77 · C14orf149 · Trans-L-3-hydroxyproline dehydratase

Resolves to

Protein
UniProtQ96EM0UniProt nameT3HPD_HUMAN
Gene
HGNCHGNC:20488NCBI Gene112849GenBank15082426GeneCardsL3HYPDH
Pharmacology
KEGGhsa:112849
Structure
PDB7QPO
Drugs

What you can answer from here — as of September 03, 2024

1DrugApproved to experimental, with action, bond type and pharmacological action
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1Pfam domainDomain architecture mapped to Pfam families and clans
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8+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Trans-3-hydroxy-L-proline dehydratase, how selective are they, and which programs against it are still in active trials?

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