Gamma-aminobutyric acid type B receptor subunit 2

BE0002340ProteinHumansGABBR2

Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:9872316, PubMed:9872744). It is acted on by 11 drugs in DrugBank.

Gene name
GABBR2
UniProtKB entry
O75899Swiss-Prot
Cellular location
Cell membrane
Residues / weight
941 residues · 105,821 Da
Also known as
G protein-coupled receptor 51 · GABA-B receptor 2 · GABA-B-R2 · GABA-BR2 · GABABR2

Resolves to

Protein
UniProtO75899UniProt nameGABR2_HUMAN
Gene
HGNCHGNC:4507NCBI Gene9568GenBank3776098GeneCardsGABBR2
Pharmacology
IUPHAR/GtoPdb241KEGGhsa:9568
Structure
PDB4F11PDB4F12PDB4MQE
Drugs

What you can answer from here — as of September 07, 2019

11DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
11GO termsFunction, process and component, as structured annotations
Sign in
3Pfam domainsDomain architecture mapped to Pfam families and clans
Sign in
48+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Gamma-aminobutyric acid type B receptor subunit 2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In