Gamma-aminobutyric acid receptor subunit beta-1

BE0002344ProteinHumansGABRB1

Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217, PubMed:26950270). It is acted on by 4 drugs in DrugBank.

Gene name
GABRB1
UniProtKB entry
P18505Swiss-Prot
Cellular location
Postsynaptic cell membrane
Residues / weight
474 residues · 54,234 Da
Also known as
GABA(A) receptor subunit beta-1 · GABAAR subunit beta-1

Resolves to

Protein
UniProtP18505UniProt nameGBRB1_HUMAN
Gene
HGNCHGNC:4081NCBI Gene2560GenBank31635GeneCardsGABRB1
Pharmacology
KEGGhsa:2560
Structure
PDB9CTVPDB9CXBPDB9CXD
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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22+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid receptor subunit beta-1, how selective are they, and which programs against it are still in active trials?

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