Guanylate kinase

BE0002351ProteinHumansGUK1

Catalyzes the phosphorylation of GMP to GDP. It is acted on by 3 drugs in DrugBank.

Gene name
GUK1
UniProtKB entry
Q16774Swiss-Prot
Cellular location
Photoreceptor inner segment
Residues / weight
197 residues · 21,725 Da
Also known as
2.7.4.8 · GMK · GMP kinase · GMPK · Guanylate kinase 1

Resolves to

Protein
UniProtQ16774UniProt nameKGUA_HUMAN
Gene
HGNCHGNC:4693NCBI Gene2987GenBank1196436GeneCardsGUK1
Pharmacology
KEGGhsa:2987
Structure
PDB6NUIPDB8PTSPDB9J8L
Drugs

What you can answer from here — as of September 07, 2019

3DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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1Metabolic reactionDrug transformations it catalyses, substrate to product
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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13+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Guanylate kinase, how selective are they, and which programs against it are still in active trials?

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