Guanylate kinase
Details
- Name
- Guanylate kinase
- Kind
- protein
- Synonyms
- 2.7.4.8
- GMK
- GMP kinase
- GMPK
- Guanylate kinase 1
- Gene Name
- GUK1
- UniProtKB Entry
- Q16774Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004617|Guanylate kinase MSGPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREV MQRDIAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYI SVQPPSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAE LKEALSEEIKKAQRTGA
- Number of residues
- 197
- Molecular Weight
- 21725.41
- Theoretical pI
- 6.53
- GO Classification
- Processesphosphorylation / xenobiotic metabolic processComponentsphotoreceptor inner segment
- General Function
- Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) (PubMed:31201273). Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors (PubMed:31201273). In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664)
- Specific Function
- ATP binding
- Pfam Domain Function
- Guanylate_kin (PF00625)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Photoreceptor inner segment
- Gene sequence
>lcl|BSEQ0011690|Guanylate kinase (GUK1) ATGTCGGGCCCCAGGCCTGTGGTGCTGAGCGGGCCTTCGGGAGCTGGGAAGAGCACCCTG CTGAAGAGGCTGCTCCAGGAGCACAGCGGCATCTTTGGCTTCAGCGTGTCCCATACCACG AGGAACCCGAGGCCCGGCGAGGAGAACGGCAAAGATTACTACTTTGTAACCAGGGAGGTG ATGCAGCGTGACATAGCAGCCGGCGACTTCATCGAGCATGCCGAGTTCTCGGGGAACCTG TATGGCACGAGCAAGGTGGCGGTGCAGGCCGTGCAGGCCATGAACCGCATCTGTGTGCTG GACGTGGACCTGCAGGGTGTGCGGAACATCAAGGCCACCGATCTGCGGCCCATCTACATC TCTGTGCAGCCGCCTTCACTGCACGTGCTGGAGCAGCGGCTGCGGCAGCGCAACACTGAA ACCGAGGAGAGCCTGGTGAAGCGGCTGGCTGCTGCCCAGGCCGACATGGAGAGCAGCAAG GAGCCCGGCCTGTTTGATGTGGTCATCATTAACGACAGCCTGGACCAGGCCTACGCAGAG CTGAAGGAGGCGCTCTCTGAGGAAATCAAGAAAGCTCAAAGGACCGGCGCCTGA
- Chromosome Location
- 1
- Locus
- 1q42.13
- External Identifiers
Resource Link UniProtKB ID Q16774 UniProtKB Entry Name KGUA_HUMAN GenBank Protein ID 1196436 GenBank Gene ID L76200 GeneCard ID GUK1 GenAtlas ID GUK1 HGNC ID HGNC:4693 PDB ID(s) 6NUI KEGG ID hsa:2987 NCBI Gene ID 2987 - General References
- Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM: Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. FEBS Lett. 1996 May 6;385(3):185-8. [Article]
- Brady WA, Kokoris MS, Fitzgibbon M, Black ME: Cloning, characterization, and modeling of mouse and human guanylate kinases. J Biol Chem. 1996 Jul 12;271(28):16734-40. [Article]
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Guanosine-5'-Monophosphate experimental unknown target Details Valaciclovir approved, investigational unknown enzyme substrate Details Acyclovir approved unknown enzyme substrate Details