Platelet-activating factor acetylhydrolase

BE0002409ProteinHumansPLA2G7

Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:16371369, PubMed:17090529, PubMed:2040620, PubMed:7700381, PubMed:8624782). It is acted on by 4 drugs in DrugBank.

Gene name
PLA2G7
UniProtKB entry
Q13093Swiss-Prot
Cellular location
Secreted, extracellular space
Residues / weight
441 residues · 50,077 Da
Also known as
1-alkyl-2-acetylglycerophosphocholine esterase · 2-acetyl-1-alkylglycerophosphocholine esterase · 3.1.1.47 · Group-VIIA phospholipase A2 · gVIIA-PLA2

Resolves to

Protein
UniProtQ13093UniProt namePAFA_HUMAN
Gene
HGNCHGNC:9040NCBI Gene7941GeneCardsPLA2G7
Pharmacology
IUPHAR/GtoPdb1432KEGGhsa:7941
Structure
PDB3D59PDB3D5EPDB3F96
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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1Clinical trialTrials of drugs acting on it, by phase and status
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9GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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24+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Platelet-activating factor acetylhydrolase, and which indications are they being tested in?

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