Nicotinamide phosphoribosyltransferase

BE0002413ProteinHumansNAMPT

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is acted on by 4 drugs in DrugBank.

Gene name
NAMPT
UniProtKB entry
P43490Swiss-Prot
Cellular location
Nucleus
Residues / weight
491 residues · 55,521 Da
Also known as
2.4.2.12 · NAmPRTase · Nampt · PBEF · PBEF1

Resolves to

Protein
UniProtP43490UniProt nameNAMPT_HUMAN
Gene
HGNCHGNC:30092NCBI Gene10135GeneCardsNAMPT
Pharmacology
KEGGhsa:10135
Structure
PDB2E5BPDB2E5CPDB2E5D
Drugs

What you can answer from here — as of September 07, 2019

4DrugsApproved to experimental, with action, bond type and pharmacological action
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2Clinical trialsTrials of drugs acting on it, by phase and status
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11GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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36+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Nicotinamide phosphoribosyltransferase, and which indications are they being tested in?

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