Fructose-1,6-bisphosphatase 1

BE0002431ProteinHumansFBP1

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. It is acted on by 13 drugs in DrugBank.

Gene name
FBP1
UniProtKB entry
P09467Swiss-Prot
Residues / weight
338 residues · 36,842 Da
Also known as
3.1.3.11 · D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 · FBP · FBPase 1 · Liver FBPase

Resolves to

Protein
UniProtP09467UniProt nameF16P1_HUMAN
Gene
HGNCHGNC:3606NCBI Gene2203GeneCardsFBP1
Pharmacology
KEGGhsa:2203
Structure
PDB1FTAPDB2FHYPDB2FIE
Drugs

What you can answer from here — as of September 07, 2019

13DrugsApproved to experimental, with action, bond type and pharmacological action
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16GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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47+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Fructose-1,6-bisphosphatase 1, how selective are they, and which programs against it are still in active trials?

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