Histamine N-methyltransferase
Details
- Name
- Histamine N-methyltransferase
- Kind
- protein
- Synonyms
- 2.1.1.8
- HMT
- Gene Name
- HNMT
- UniProtKB Entry
- P50135Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0004783|Histamine N-methyltransferase MASSMRSLFSDHGKYVESFRRFLNHSTEHQCMQEFMDKKLPGIIGRIGDTKSEIKILSIG GGAGEIDLQILSKVQAQYPGVCINNEVVEPSAEQIAKYKELVAKTSNLENVKFAWHKETS SEYQSRMLEKKELQKWDFIHMIQMLYYVKDIPATLKFFHSLLGTNAKMLIIVVSGSSGWD KLWKKYGSRFPQDDLCQYITSDDLTQMLDNLGLKYECYDLLSTMDISDCFIDGNENGDLL WDFLTETCNFNATAPPDLRAELGKDLQEPEFSAKKEGKVLFNNTLSFIVIEA
- Number of residues
- 292
- Molecular Weight
- 33294.765
- Theoretical pI
- 4.98
- GO Classification
- Processeshistamine catabolic process / histamine metabolic process / L-histidine catabolic process / respiratory gaseous exchange by respiratory systemComponentscentrosome
- General Function
- Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine
- Specific Function
- histamine N-methyltransferase activity
- Pfam Domain Function
- Methyltransf_23 (PF13489)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011743|Histamine N-methyltransferase (HNMT) ATGGCATCTTCCATGAGGAGCTTGTTTTCTGACCACGGGAAATATGTTGAATCTTTCCGG AGGTTTCTCAACCATTCCACGGAACACCAGTGCATGCAGGAATTCATGGACAAGAAGCTG CCAGGCATAATAGGAAGATACCAGAATTGCTGTTAA
- Chromosome Location
- 2
- Locus
- 2q22.1
- External Identifiers
Resource Link UniProtKB ID P50135 UniProtKB Entry Name HNMT_HUMAN GenBank Gene ID D16224 GeneCard ID HNMT GenAtlas ID HNMT HGNC ID HGNC:5028 PDB ID(s) 1JQD, 1JQE, 2AOT, 2AOU, 2AOV, 2AOW, 2AOX KEGG ID hsa:3176 NCBI Gene ID 3176 - General References
- Yamauchi K, Sekizawa K, Suzuki H, Nakazawa H, Ohkawara Y, Katayose D, Ohtsu H, Tamura G, Shibahara S, Takemura M, et al.: Structure and function of human histamine N-methyltransferase: critical enzyme in histamine metabolism in airway. Am J Physiol. 1994 Sep;267(3 Pt 1):L342-9. [Article]
- Girard B, Otterness DM, Wood TC, Honchel R, Wieben ED, Weinshilboum RM: Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA. Mol Pharmacol. 1994 Mar;45(3):461-8. [Article]
- Aksoy S, Raftogianis R, Weinshilboum R: Human histamine N-methyltransferase gene: structural characterization and chromosomal location. Biochem Biophys Res Commun. 1996 Feb 15;219(2):548-54. [Article]
- Barnes WG, Grinde E, Crawford DR, Herrick-Davis K, Hough LB: Characterization of a new mRNA species from the human histamine N-methyltransferase gene. Genomics. 2004 Jan;83(1):168-71. [Article]
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- Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X: Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure. 2001 Sep;9(9):837-49. [Article]
- Preuss CV, Wood TC, Szumlanski CL, Raftogianis RB, Otterness DM, Girard B, Scott MC, Weinshilboum RM: Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. Mol Pharmacol. 1998 Apr;53(4):708-17. [Article]
- Yan L, Galinsky RE, Bernstein JA, Liggett SB, Weinshilboum RM: Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. Pharmacogenetics. 2000 Apr;10(3):261-6. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Amodiaquine approved, investigational yes target inhibitor Details S-adenosyl-L-homocysteine experimental yes target inhibitor Details Metoprine experimental yes target inhibitor Details Histamine approved, investigational unknown enzyme substrate Details Quinacrine investigational unknown enzyme inhibitor Details S-adenosyl-L-homocysteine experimental unknown enzyme inhibitorbinder Details SKF-91488 experimental yes target inhibitor Details Harmaline experimental unknown target inhibitor Details Diphenhydramine approved, investigational yes target inhibitor Details